Cleared Nanoparticles for Medical Use
Nanoparticles Approved in the United States (US) and Europe (EU) for Medical Applications
This list includes all nanoparticles currently approved for medical use in the United States by the Food and Drug Administration (FDA) and in Europe by the European Medicines Agency (EMA). download list
|
Name (developer) |
Nanoparticle Class |
Indication(s) [Approval Year & Region] |
Links |
|
Adagen® Pegademase bovine (Sigma-Tau Pharmaceuticals) |
Polymer Nanoparticle |
Adensine deaminase (ADA) deficiency in patients with severe combined immunodeficiency disease (SCID) [1990 US] |
www.adagen.com |
|
Adynovate® Antihemophilic factor (recombinant), PEGylated (Shire) |
Polymer Nanoparticle |
Hemophilia [2015 US] |
www.adynovate.com |
|
Cimzia® Certolizumab pegol (UCB) |
Polymer Nanoparticle | Crohn’s disease [2008 US] [2009 EU] Rheumatoid arthritis[2009 US] [2009 EU] Psoriatic arthritis[2013 US] [2009 EU] Ankylosing spondylitis[2013 US] [2009 EU] |
|
|
Copaxone®; Glatopa ® Glatiramer acetate (Teva Neuroscience) |
Polymer Nanoparticle |
Multiple sclerosis (MS) [1996 US] |
|
|
Eligard® Leuprolide acetate (Tolmar Pharmaceuticals) |
Polymer Nanoparticle |
Prostate cancer [2002 US] |
|
|
Krystexxa® Pegloticase (Crealta Pharmaceuticals) |
Polymer Nanoparticle |
Chronic gout [2010 US] [2013 EU] |
|
|
LC Bead LUMITM/DC Bead LUMITM (Biocompatibles UK) |
Polymer Nanoparticle |
Hypervascular tumors and arteriovenous malformations (AVMs) [2015 US] [2017 EU] |
|
|
Macugen® Pegaptanib (Bausch & Lomb) |
Polymer Nanoparticle |
Neovascular age-related macular degeneration [2004 US] [2006 EU] |
|
|
Mircera® mPEG-epoetin beta (Roche) |
Polymer Nanoparticle |
Anemia associated with chronic kidney disease [2007 US/EU] |
|
|
Neulasta® Pegfilgrastim (Amgen) |
Polymer Nanoparticle |
Chemotherapy induced neutropenia [2002 US/EU] |
|
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Oncaspar® Pegaspargase (Shire) |
Polymer Nanoparticle |
Acute lymphoblastic leukemia [1994 US] [2016 EU] |
|
|
Pegasys® Peginterferon alpha-2a (Roche) |
Polymer Nanoparticle |
Hepatitis B and C [2002 US/EU] |
|
|
PegIntron® Peginterferon alpha-2a (Merck) |
Polymer Nanoparticle |
Hepatitis C [2001 US] [2000 EU] |
Discontinued in 2015 |
|
Plegridy® Peginterferon beta-1a (Biogen) |
Polymer Nanoparticle |
Multiple sclerosis (MS) [2014 US/EU] |
|
|
Renvela®/Renagel® Sevelamer hydrochloride (Genzyme) |
Polymer Nanoparticle |
Chronic kidney disease [2000 US/EU] |
|
|
Somavert® Pegvisomant (Pfizer) |
Polymer Nanoparticle |
Acromegaly [2003 US] [2002 EU] |
|
|
Welchol® Colesevelam hydrochloride (Daiichi-Sankyo) |
Polymer Nanoparticle |
Type II diabetes [2000 US] |
|
|
Abelcet® Amphotericin B (Sigma-Tau Pharmaceuticals) |
Liposome Nanoparticle |
Fungal infections [1995 US] |
|
|
AmBisome® Amphotericin B (Gilead Sciences) |
Liposome Nanoparticle |
Fungal/protozoal infections [1997 US] |
|
|
Curosurf® Poractant alpha (Chiesei) |
Liposome Nanoparticle |
Respiratory distress syndrome [1999 US] |
|
|
DaunoXome® Daunorubicin (Galen) |
Liposome Nanoparticle |
Kaposi’s sarcoma [1996 US] |
Discontinued 2016 |
|
DepoCyt© Cytarabine (Pacira Pharmaceuticals) |
Liposome Nanoparticle |
Lymphomatous meningitis [1999 US] [2001 EU] |
|
|
DepoDur® Morphine sulfate (Pacira Pharmaceuticals) |
Liposome Nanoparticle |
Analgesia (post-operative) [2004 US] |
|
|
Doxil®/CaelyxTM Doxorubicin (Janssen) |
Liposome Nanoparticle |
Karposi’s sarcoma [1995 US] [1996 EU] Ovarian cancer [2005 US] [1996 EU] Multiple myeloma [2008 US] [1996 EU] Breast cancer [1996 EU] |
|
|
Marqibo® Vincristine sulfate (Spectrum Pharmaceuticals) |
Liposome Nanoparticle |
Acute lymphoblastic leukemia [2012 US] |
|
|
Mepact® Mifamurtide (IDM Pharma) |
Liposome Nanoparticle |
Bone cancer [2009 EU] |
|
|
Myocet® Doxorubicin (Teva UK) |
Liposome Nanoparticle |
Bone cancer [2000 EU] |
|
|
Onivyde® Irinotecan hydrochloride (Ipsen Biopharmaceuticals) |
Liposome Nanoparticle |
Pancreatic cancer [2015 US] [2016 EU] |
|
|
Visudyne® Verteporfin (Novartis) |
Liposome Nanoparticle |
Age-related macular degeneration [2000 US/EU] Pathologic myopia [2000 US/EU] Ocular histoplasmosis [2000 US/EU] |
|
|
EstrasorbTM Estradiol hemihydrate (Novavax/Graceway) |
Micellar Nanoparticle |
Menopausal therapy [2003 US] |
|
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Taxol® Paclitaxel (Bristol Myres Squibb) |
Micellar Nanoparticle |
Ovarian cancer [1992 US] Breast cancer [1994 US] Kaposi’s sarcoma [1997 US] Non-small cell lung cancer [1998 US] |
|
|
Taxotere® Docetaxel (Sanofi-Aventis) |
Micellar Nanoparticle |
Breast Cancer [1996 US] [1995 EU] Non-small cell lung cancer [1999 US] [1995 EU] Prostate cancer [2004 US] [1995 EU] Gastric cancer [2006 US] [1995 EU] Head and neck cancer [2006 US] [1995 EU] |
|
|
Abraxane® ABI-007 Protein-bound paclitaxel (Celgene) |
Protein Nanoparticle |
Breast cancer [2005 US] [2008 EU] Non-small cell lung cancer [2012 US] [2005 EU] Pancreatic cancer [2013 US] [2008 EU] |
|
|
Ontak® Denileukin diftitox (Eisai) |
Protein Nanoparticle |
Cutaneous T-cell lymphoma [1999 US] |
Discontinued 2014 |
|
Avinza® Morphine sulfate (Pfizer) |
Nanocrystals |
Pain management [2002 US] |
Discontinued 2015 |
|
Emend® Aprepitant (Merck) |
Nanocrystals |
Antiemetic [2003 US/EU] |
|
|
EquivaBone® (Zimmer Biomet) |
Nanocrystals |
Bone substitute [2009 US] |
equivabone.com |
|
Focalin XR® Dexmethylphenidate hydrochloride (Novartis) |
Nanocrystals |
Attention deficit hyperactivity disorder [2005 US] |
|
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Invega Sustenna®/Xeplion® Paliperidone palmitate (Janssen Pharms) |
Nanocrystals |
Schizophrenia [2009 US] [2011 EU] |
|
|
Megace ES® Megestrol acetate (Endo Pharms) |
Nanocrystals |
Anti-anorexic [2005 US] |
Wikipedia |
|
NanOss® (Rti Surgical) |
Nanocrystals |
Bone substitute [2005 US] |
nanoss.com |
|
OsSatura® (IsoTis Orthobiologics) |
Nanocrystals |
Bone substitute [2003 US] |
Recalled 2006 |
|
Ostim® (Heraseus Kulzer) |
Nanocrystals |
Bone substitute [2004 US] |
Ostim - Product Information |
|
Rapamune® Sirolimus (Pfizer) |
Nanocrystals |
Immunosuppresent [1999 US] [2001 EU] |
|
|
Ritalin LA® Methylphenidate hydrochloride (Novartis) |
Nanocrystals |
Attention deficit hyperactivity disorder [2002 US] |
|
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Ryanodex® Dantrolene sodium (Eagle Pharmaceuticals) |
Nanocrystals |
Malignant hypothermia [2014 US] |
|
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Tricor® Fenofibrate (AbbVie) |
Nanocrystals |
High cholesterol and high triglyceride levels [2004 US] |
Wikipedia |
|
Triglide® Fenofibrate (SkyePharma AG) |
Nanocrystals |
High cholesterol and triglycerides [2005 US] |
Drugs@FDA - Prescribing Information |
|
Vitoss® (Stryker) |
Nanocrystals |
Bone substitute [2003 US] |
|
|
Zanaflex® Tizanidine hydrochloride (Acorda) |
Nanocrystals |
Muscle relaxant [1996 US] |
|
|
Dexferrum®/ DexIron® (Luitpold Pharmaceuticals) |
Inorganic and Metallic Nanoparticles |
Iron deficiency [1996 US] |
|
|
FerahemeTM/Rienso® Ferumoxytol (AMAG pharmaceuticals) |
Inorganic and Metallic Nanoparticles |
Iron deficiency anemia in chronic kidney disease [2009 US] [2012 EU] |
|
|
Feridex®/Endorem® (AMAG pharmaceuticals) |
Inorganic and Metallic Nanoparticles |
Magnetic Resonance Imaging (MRI) agent [1996 US] |
Discontinued 2008 |
|
Ferrlecit® (Sanofi Avertis) |
Inorganic and Metallic Nanoparticles |
Iron deficiency anemia in chronic kidney disease [1999 US] |
|
|
GastroMARKTM/ Lumirem® (AMAG pharmaceuticals) |
Inorganic and Metallic Nanoparticles |
Magnetic Resonance Imaging (MRI) agent [1996 US/EU] |
Discontinued 2012 |
|
INFeD® (Allergan Pharma) |
Inorganic and Metallic Nanoparticles |
Iron deficiency anemia in chronic kidney disease [1974 US] |
|
|
Injectafer®/Ferinject® (Luitpold Pharmaceuticals) |
Inorganic and Metallic Nanoparticles |
Iron deficiency anemia in chronic kidney disease [2013 US] |
|
|
Resovist®/CliavistTM (Bayer Schering Pharma) |
Inorganic and Metallic Nanoparticles |
Magnetic Resonance Imaging (MRI) agent [2001 EU] |
Abandoned 2009 |
|
Venofer® (Luitpold Pharmaceuticals) |
Inorganic and Metallic Nanoparticles |
Iron deficiency anemia in chronic kidney disease [2000 US] |
|
|
Inflexal® V (Berna Biotech/Crucell) |
Virosome Nanoparticle | Influenza | eMC - Patient Information |
Last Updated: July 28, 2017
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Nanoparticles Approved in the United States (US) and Europe (EU) for Medical Applications: